Expression of CD163 in cancer - Summary

GENERAL INFORMATION
Gene name	CD163
Gene description	CD163 molecule
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Not detected
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in immune cells in all tissues, including Hofbauer cells, Kupffer cells and alveolar macrophages.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 3 antibodies. HPA046404 , HPA051974 , CAB002432
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA046404	HPA051974	CAB002432

GENE INFORMATION
Gene name	CD163 (HGNC Symbol)
Synonyms	M130, MM130
Description	CD163 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7470813 - 7503893
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177575 (version 83.38)
Entrez gene	9332
UniProt	Q86VB7 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VB7
Antibodypedia	CD163 antibodies

PROTEIN BROWSER

CD163-001	CD163-002	CD163-003	CD163-005	CD163-007	CD163-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD163-001 ENSP00000352071 ENST00000359156	Q86VB7 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006953 [acute-phase response] GO:0016020 [membrane] GO:0030666 [endocytic vesicle membrane] Show all	1156 aa 125.5 kDa	No	1
CD163-002 ENSP00000403885 ENST00000432237	Q86VB7 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006953 [acute-phase response] GO:0016020 [membrane] GO:0030666 [endocytic vesicle membrane] Show all	1121 aa 121.6 kDa	No	1
CD163-003 ENSP00000379863 ENST00000396620	C9JHR8 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M130 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1154 aa 124.9 kDa	No	1
CD163-005 ENSP00000444071 ENST00000541972	F5GZZ9 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M130 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1109 aa 120.3 kDa	Yes	1
CD163-007 ENSP00000439226 ENST00000537626	H0YFM0 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M130 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	137 aa 15 kDa	No	1
CD163-009 ENSP00000445438 ENST00000542280	H0YGZ7 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M130 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	124 aa 13.4 kDa	No	0