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ACAD9

GENERAL INFORMATION

Gene name

 ACAD9

Gene description

 Acyl-CoA dehydrogenase family, member 9

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA037716
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037716

GENE INFORMATION

Gene name

 ACAD9 (HGNC Symbol)

Synonyms

 MGC14452, NPD002

Description

 Acyl-CoA dehydrogenase family, member 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 128879596 - 128916067

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177646 (version 83.38)

Entrez gene

 28976

UniProt

 Q9H845 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H845

Antibodypedia

 ACAD9 antibodies

PROTEIN BROWSER
ACAD9-001
ACAD9-014
ACAD9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACAD9-001
ENSP00000312618
ENST00000308982
Q9H845 [Direct mapping]
Acyl-CoA dehydrogenase family member 9, mitochondrial
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0030425 [dendrite]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
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 621 aa
68.8 kDa 		No 0
ACAD9-014
ENSP00000423758
ENST00000514336
D6RCD8 [Direct mapping]
Acyl-CoA dehydrogenase family member 9, mitochondrial
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   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 173 aa
19 kDa 		No 0
ACAD9-201
ENSP00000478191
ENST00000620948
A0A087WTX1 [Direct mapping]
Acyl-CoA dehydrogenase family member 9, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 168 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.