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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACAD9
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACAD9

Gene description

Acyl-CoA dehydrogenase family, member 9

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 1 antibody.
HPA037716
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA037716

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern.

GENE INFORMATION

Gene name

ACAD9 (HGNC Symbol)

Synonyms

MGC14452, NPD002

Description

Acyl-CoA dehydrogenase family, member 9 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Chromosome

3

Cytoband

q21.3

Chromosome location (bp)

128879596 - 128916067

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177646 (version 83.38)

Entrez gene

28976

UniProt

Q9H845 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H845

Antibodypedia

ACAD9 antibodies

PROTEIN BROWSER

ACAD9-001
ACAD9-014
ACAD9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACAD9-001
ENSP00000312618
ENST00000308982
Q9H845 [Direct mapping]
Acyl-CoA dehydrogenase family member 9, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0030425 [dendrite]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
621 aa
68.8 kDa
No 0
ACAD9-014
ENSP00000423758
ENST00000514336
D6RCD8 [Direct mapping]
Acyl-CoA dehydrogenase family member 9, mitochondrial
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
173 aa
19 kDa
No 0
ACAD9-201
ENSP00000478191
ENST00000620948
A0A087WTX1 [Direct mapping]
Acyl-CoA dehydrogenase family member 9, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
168 aa
18.7 kDa
No 0

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