Expression of AGTRAP in cancer - Summary

GENERAL INFORMATION
Gene name	AGTRAP
Gene description	Angiotensin II receptor-associated protein
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, in many cases with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA044120
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA044120

GENE INFORMATION
Gene name	AGTRAP (HGNC Symbol)
Synonyms	ATRAP
Description	Angiotensin II receptor-associated protein (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11736084 - 11754802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177674 (version 83.38)
Entrez gene	57085
UniProt	Q6RW13 (UniProt - Evidence at protein level)
neXtProt	NX_Q6RW13
Antibodypedia	AGTRAP antibodies

PROTEIN BROWSER

AGTRAP-001	AGTRAP-002	AGTRAP-003	AGTRAP-005	AGTRAP-010	AGTRAP-011	AGTRAP-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGTRAP-001 ENSP00000319713 ENST00000314340	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001666 [response to hypoxia] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0008217 [regulation of blood pressure] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0038166 [angiotensin-activated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] Show all	159 aa 17.4 kDa	No	3
AGTRAP-002 ENSP00000365816 ENST00000376629	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	152 aa 16.7 kDa	No	3
AGTRAP-003 ENSP00000365824 ENST00000376637	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	111 aa 11.9 kDa	No	0
AGTRAP-005 ENSP00000365814 ENST00000376627	X6R9H3 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 17.3 kDa	No	0
AGTRAP-010 ENSP00000383688 ENST00000400895	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	147 aa 16 kDa	No	0
AGTRAP-011 ENSP00000408505 ENST00000452018	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	155 aa 17 kDa	No	0
AGTRAP-012 ENSP00000422647 ENST00000510878	D6RBK6 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 16.4 kDa	Yes	0