Tissue expression of AGTRAP - Summary - The Human Protein Atlas

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AGTRAP

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AGTRAP
Gene description	Angiotensin II receptor-associated protein
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types, in many cases with a granular pattern.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA044120
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	AGTRAP (HGNC Symbol)
Synonyms	ATRAP
Description	Angiotensin II receptor-associated protein (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11736084 - 11754802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177674 (version 83.38)
Entrez gene	57085
UniProt	Q6RW13 (UniProt - Evidence at protein level)
neXtProt	NX_Q6RW13
Antibodypedia	AGTRAP antibodies

PROTEIN BROWSER

AGTRAP-001	AGTRAP-002	AGTRAP-003	AGTRAP-005	AGTRAP-010	AGTRAP-011	AGTRAP-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGTRAP-001 ENSP00000319713 ENST00000314340	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001666 [response to hypoxia] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0008217 [regulation of blood pressure] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0038166 [angiotensin-activated signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] Show all	159 aa 17.4 kDa	No	3
AGTRAP-002 ENSP00000365816 ENST00000376629	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	152 aa 16.7 kDa	No	3
AGTRAP-003 ENSP00000365824 ENST00000376637	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	111 aa 11.9 kDa	No	0
AGTRAP-005 ENSP00000365814 ENST00000376627	X6R9H3 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 17.3 kDa	No	0
AGTRAP-010 ENSP00000383688 ENST00000400895	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	147 aa 16 kDa	No	0
AGTRAP-011 ENSP00000408505 ENST00000452018	Q6RW13 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	155 aa 17 kDa	No	0
AGTRAP-012 ENSP00000422647 ENST00000510878	D6RBK6 [Direct mapping] Type-1 angiotensin II receptor-associated protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 16.4 kDa	Yes	0

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