Expression of CRACR2B in cancer - Summary - The Human Protein Atlas

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CRACR2B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRACR2B
Gene description	Calcium release activated channel regulator 2B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SK-BR-3)
HPA (normal tissue):	Tissue enhanced (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA046217
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046217

GENE INFORMATION
Gene name	CRACR2B (HGNC Symbol)
Synonyms	EFCAB4A, MGC45840
Description	Calcium release activated channel regulator 2B (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	826144 - 831991
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177685 (version 83.38)
Entrez gene	283229
UniProt	Q8N4Y2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4Y2
Antibodypedia	CRACR2B antibodies

PROTEIN BROWSER

CRACR2B-001	CRACR2B-007	CRACR2B-009	CRACR2B-010	CRACR2B-011	CRACR2B-012	CRACR2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRACR2B-001 ENSP00000432334 ENST00000528542	Q8N4Y2 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Show all	GO:0002115 [store-operated calcium entry] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	294 aa 32.7 kDa	No	0
CRACR2B-007 ENSP00000435299 ENST00000525077	Q8N4Y2 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Show all	GO:0002115 [store-operated calcium entry] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:2001256 [regulation of store-operated calcium entry] Show all	399 aa 45 kDa	No	0
CRACR2B-009 ENSP00000436624 ENST00000530183	E9PHZ8 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	53 aa 5.6 kDa	No	0
CRACR2B-010 ENSP00000433602 ENST00000533803	E9PK04 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Show all		81 aa 8.6 kDa	No	0
CRACR2B-011 ENSP00000432726 ENST00000527089	E9PPF3 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	88 aa 9.5 kDa	No	0
CRACR2B-012 ENSP00000434198 ENST00000528315	E9PRE5 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Show all		34 aa 3.4 kDa	No	0
CRACR2B-201 ENSP00000409256 ENST00000450448	Q8N4Y2 [Direct mapping] EF-hand calcium-binding domain-containing protein 4A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002115 [store-operated calcium entry] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	294 aa 32.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.