Expression of NAALADL2 in cancer - Summary - The Human Protein Atlas

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NAALADL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NAALADL2
Gene description	N-acetylated alpha-linked acidic dipeptidase-like 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (ASC TERT1, T-47d, WM-115)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression mainly in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Pending retesting.
Reliability score	Approved based on 3 antibodies. HPA012413 , HPA017425 , CAB025586
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012413	HPA017425	CAB025586

GENE INFORMATION
Gene name	NAALADL2
Synonyms
Description	N-acetylated alpha-linked acidic dipeptidase-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q26.31
Chromosome location (bp)	174438573 - 175810552
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177694 (version 83.38)
Entrez gene	254827
UniProt	Q58DX5 (UniProt - Evidence at protein level)
neXtProt	NX_Q58DX5
Antibodypedia	NAALADL2 antibodies

PROTEIN BROWSER

NAALADL2-001	NAALADL2-006	NAALADL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAALADL2-001 ENSP00000404705 ENST00000454872	Q58DX5 [Direct mapping] Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	795 aa 88.7 kDa	No	1
NAALADL2-006 ENSP00000409858 ENST00000434257	C9JQ86 [Direct mapping] Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.1 kDa	No	0
NAALADL2-201 ENSP00000479989 ENST00000614002	A0A087WW67 [Direct mapping] Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	783 aa 87.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.