Expression of FLII in cancer - Summary - The Human Protein Atlas

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FLII

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FLII
Gene description	Flightless I actin binding protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, also expressed in the nucleus.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA007084 , HPA008903 , CAB016132
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007084	HPA008903	CAB016132

GENE INFORMATION
Gene name	FLII (HGNC Symbol)
Synonyms	FLI, Fli1, FLIL, MGC39265
Description	Flightless I actin binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	18244836 - 18258916
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177731 (version 83.38)
Entrez gene	2314
UniProt	Q13045 (UniProt - Evidence at protein level)
neXtProt	NX_Q13045
Antibodypedia	FLII antibodies

PROTEIN BROWSER

FLII-001	FLII-018	FLII-019	FLII-021	FLII-024	FLII-026	FLII-028	FLII-030	FLII-032	FLII-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLII-001 ENSP00000324573 ENST00000327031	Q13045 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] Show all	1269 aa 144.8 kDa	No	0
FLII-018 ENSP00000463534 ENST00000579294	Q13045 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005925 [focal adhesion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1258 aa 143.7 kDa	No	0
FLII-019 ENSP00000438536 ENST00000545457	Q13045 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005925 [focal adhesion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1214 aa 138.5 kDa	No	0
FLII-021 ENSP00000467212 ENST00000473425	K7EP37 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] Show all	99 aa 11.1 kDa	No	0
FLII-024 ENSP00000463675 ENST00000577485	J3QLR6 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] Show all	185 aa 21.2 kDa	No	0
FLII-026 ENSP00000462314 ENST00000578558	J3KS54 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] Show all	700 aa 78.1 kDa	No	0
FLII-028 ENSP00000467199 ENST00000581349	K7EP27 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] Show all	133 aa 15 kDa	No	0
FLII-030 ENSP00000468045 ENST00000577398	K7EQZ7 [Direct mapping] Protein flightless-1 homolog Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] Show all	207 aa 23.7 kDa	No	0
FLII-032 ENSP00000463838 ENST00000488932	J3QQQ2 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] Show all	279 aa 31.6 kDa	No	0
FLII-201 ENSP00000486754 ENST00000628188	J3KS39 [Direct mapping] Protein flightless-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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