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FLII

GENERAL INFORMATION

Gene name

 FLII

Gene description

 Flightless I actin binding protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, also expressed in the nucleus.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA007084 , HPA008903 , CAB016132
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FLII (HGNC Symbol)

Synonyms

 FLI, Fli1, FLIL, MGC39265

Description

 Flightless I actin binding protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 18244836 - 18258916

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177731 (version 83.38)

Entrez gene

 2314

UniProt

 Q13045 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13045

Antibodypedia

 FLII antibodies

PROTEIN BROWSER
FLII-001
FLII-018
FLII-019
FLII-021
FLII-024
FLII-026
FLII-028
FLII-030
FLII-032
FLII-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLII-001
ENSP00000324573
ENST00000327031
Q13045 [Direct mapping]
Protein flightless-1 homolog
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
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 1269 aa
144.8 kDa 		No 0
FLII-018
ENSP00000463534
ENST00000579294
Q13045 [Direct mapping]
Protein flightless-1 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1258 aa
143.7 kDa 		No 0
FLII-019
ENSP00000438536
ENST00000545457
Q13045 [Direct mapping]
Protein flightless-1 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1214 aa
138.5 kDa 		No 0
FLII-021
ENSP00000467212
ENST00000473425
K7EP37 [Direct mapping]
Protein flightless-1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
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 99 aa
11.1 kDa 		No 0
FLII-024
ENSP00000463675
ENST00000577485
J3QLR6 [Direct mapping]
Protein flightless-1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
Show all
 185 aa
21.2 kDa 		No 0
FLII-026
ENSP00000462314
ENST00000578558
J3KS54 [Direct mapping]
Protein flightless-1 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
Show all
 700 aa
78.1 kDa 		No 0
FLII-028
ENSP00000467199
ENST00000581349
K7EP27 [Direct mapping]
Protein flightless-1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
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 133 aa
15 kDa 		No 0
FLII-030
ENSP00000468045
ENST00000577398
K7EQZ7 [Direct mapping]
Protein flightless-1 homolog
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
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 207 aa
23.7 kDa 		No 0
FLII-032
ENSP00000463838
ENST00000488932
J3QQQ2 [Direct mapping]
Protein flightless-1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
Show all
 279 aa
31.6 kDa 		No 0
FLII-201
ENSP00000486754
ENST00000628188
J3KS39 [Direct mapping]
Protein flightless-1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.