Cell atlas - HNRNPA0 - The Human Protein Atlas

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HNRNPA0

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HNRNPA0
Gene description	Heterogeneous nuclear ribonucleoprotein A0
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA036569 , HPA059404
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036569	A-431	Nucleoplasm
	HPA036569	U-2 OS	Nucleoplasm	Intensity	Intensity
	HPA036569	U-251 MG	Nucleoplasm	Intensity
	HPA059404	A-431	Nucleoplasm
	HPA059404	U-2 OS	Nucleoplasm
	HPA059404	U-251 MG	Nucleoplasm

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA036569	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. HNRNPA0 is mostly expressed during G1, and during Mitosis.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nucleoplasm

siRNA VALIDATION

Antibody

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

29%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA036569	siRNA 1	U-2 OS
		HPA036569	scrambled	U-2 OS

GENE INFORMATION
Gene name	HNRNPA0 (HGNC Symbol)
Synonyms	hnRNPA0, HNRPA0
Description	Heterogeneous nuclear ribonucleoprotein A0 (HGNC Symbol)
Entrez gene summary	This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.2
Chromosome location (bp)	137745651 - 137754376
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177733 (version 83.38)
Entrez gene	10949
UniProt	Q13151 (UniProt - Evidence at protein level)
neXtProt	NX_Q13151
Antibodypedia	HNRNPA0 antibodies

PROTEIN BROWSER

HNRNPA0-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HNRNPA0-001 ENSP00000316042 ENST00000314940	Q13151 [Direct mapping] Heterogeneous nuclear ribonucleoprotein A0 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006397 [mRNA processing] GO:0006954 [inflammatory response] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0017091 [AU-rich element binding] GO:0019901 [protein kinase binding] GO:0030529 [ribonucleoprotein complex] GO:0032496 [response to lipopolysaccharide] GO:0044822 [poly(A) RNA binding] GO:0070935 [3'-UTR-mediated mRNA stabilization] Show all	305 aa 30.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.