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HNRNPA0

GENERAL INFORMATION

Gene name

 HNRNPA0

Gene description

 Heterogeneous nuclear ribonucleoprotein A0

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA036569 , HPA059404
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036569
HPA059404

GENE INFORMATION

Gene name

 HNRNPA0 (HGNC Symbol)

Synonyms

 hnRNPA0, HNRPA0

Description

 Heterogeneous nuclear ribonucleoprotein A0 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 137745651 - 137754376

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177733 (version 83.38)

Entrez gene

 10949

UniProt

 Q13151 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13151

Antibodypedia

 HNRNPA0 antibodies

PROTEIN BROWSER
HNRNPA0-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HNRNPA0-001
ENSP00000316042
ENST00000314940
Q13151 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A0
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0006954 [inflammatory response]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0032496 [response to lipopolysaccharide]
GO:0044822 [poly(A) RNA binding]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
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 305 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.