Cell atlas - RPS27 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RPS27
Gene description	Ribosomal protein S27
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & endoplasmic reticulum. In addition localized to the nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066851
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & endoplasmic reticulum. In addition localized to the nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Endoplasmic reticulum (approved), Cytosol (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA066851	Hep G2	Endoplasmic reticulum
HPA066851	Hep G2	Cytosol
HPA066851	SK-MEL-30	Endoplasmic reticulum
HPA066851	SK-MEL-30	Cytosol
HPA066851	U-2 OS	Nucleoli
		Endoplasmic reticulum
		Cytosol

GENE INFORMATION
Gene name	RPS27 (HGNC Symbol)
Synonyms	MPS-1, MPS1, S27
Description	Ribosomal protein S27 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153990759 - 153992150
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177954 (version 83.38)
Entrez gene	6232
UniProt	P42677 (UniProt - Evidence at protein level)
neXtProt	NX_P42677
Antibodypedia	RPS27 antibodies

PROTEIN BROWSER

RPS27-001	RPS27-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS27-001 ENSP00000357555 ENST00000368567	P42677 [Direct mapping] 40S ribosomal protein S27 Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000278 [mitotic cell cycle] GO:0003677 [DNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0007264 [small GTPase mediated signal transduction] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0022627 [cytosolic small ribosomal subunit] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] Show all	84 aa 9.5 kDa	No	0
RPS27-002 ENSP00000376341 ENST00000392558	Q5T4L4 [Direct mapping] 40S ribosomal protein S27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	66 aa 7.4 kDa	No	0