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RPS27

GENERAL INFORMATION

Gene name

 RPS27

Gene description

 Ribosomal protein S27

Protein class

 Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RPS27 (HGNC Symbol)

Synonyms

 MPS-1, MPS1, S27

Description

 Ribosomal protein S27 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153990759 - 153992150

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177954 (version 83.38)

Entrez gene

 6232

UniProt

 P42677 (UniProt - Evidence at protein level)

neXtProt

 NX_P42677

Antibodypedia

 RPS27 antibodies

PROTEIN BROWSER
RPS27-001
RPS27-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS27-001
ENSP00000357555
ENST00000368567
P42677 [Direct mapping]
40S ribosomal protein S27
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Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 84 aa
9.5 kDa 		No 0
RPS27-002
ENSP00000376341
ENST00000392558
Q5T4L4 [Direct mapping]
40S ribosomal protein S27
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 66 aa
7.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.