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GEN1

GENERAL INFORMATION

Gene name

 GEN1

Gene description

 GEN1 Holliday junction 5' flap endonuclease

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA020078 , HPA021141
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 GEN1 (HGNC Symbol)

Synonyms

 FLJ40869, Gen

Description

 GEN1 Holliday junction 5' flap endonuclease (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p24.2

Chromosome location (bp)

 17753858 - 17788941

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178295 (version 83.38)

Entrez gene

 348654

UniProt

 Q17RS7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q17RS7

Antibodypedia

 GEN1 antibodies

PROTEIN BROWSER
GEN1-001
GEN1-002
GEN1-003
GEN1-006
GEN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEN1-001
ENSP00000318977
ENST00000317402
Q17RS7 [Direct mapping]
Flap endonuclease GEN homolog 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010824 [regulation of centrosome duplication]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:0071139 [resolution of recombination intermediates]
GO:0071140 [resolution of mitotic recombination intermediates]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 908 aa
102.9 kDa 		No 0
GEN1-002
ENSP00000435143
ENST00000524465
E9PLG0 [Direct mapping]
Flap endonuclease GEN homolog 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 126 aa
14.4 kDa 		No 0
GEN1-003
ENSP00000433180
ENST00000532257
E9PM30 [Direct mapping]
Flap endonuclease GEN homolog 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 93 aa
10.7 kDa 		No 0
GEN1-006
ENSP00000481385
ENST00000534451
A0A087WXY3 [Direct mapping]
Flap endonuclease GEN homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 129 aa
15.7 kDa 		No 0
GEN1-201
ENSP00000370653
ENST00000381254
Q17RS7 [Direct mapping]
Flap endonuclease GEN homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010824 [regulation of centrosome duplication]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:0071139 [resolution of recombination intermediates]
GO:0071140 [resolution of mitotic recombination intermediates]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 908 aa
102.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.