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KCNG2

GENERAL INFORMATION

Gene name

 KCNG2

Gene description

 Potassium channel, voltage gated modifier subfamily G, member 2

Protein class

 Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in astrocyte end-feet in hippocampus and cerebral cortex.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining mainly consistent with GTEx RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA048628
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA048628

GENE INFORMATION

Gene name

 KCNG2 (HGNC Symbol)

Synonyms

 KCNF2, Kv6.2

Description

 Potassium channel, voltage gated modifier subfamily G, member 2 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q23

Chromosome location (bp)

 79863668 - 79900184

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178342 (version 83.38)

Entrez gene

 26251

UniProt

 Q9UJ96 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJ96

Antibodypedia

 KCNG2 antibodies

PROTEIN BROWSER
KCNG2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNG2-001
ENSP00000315654
ENST00000316249
Q9UJ96 [Direct mapping]
Potassium voltage-gated channel subfamily G member 2
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008016 [regulation of heart contraction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071805 [potassium ion transmembrane transport]
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 466 aa
51.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.