Expression of CALML5 in cancer - Summary

GENERAL INFORMATION
Gene name	CALML5
Gene description	Calmodulin-like 5
Protein class	Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, cervical cancer, head and neck cancer, melanoma, urothelial cancer)
HPA (cell line):	Cell line enriched (A-431)
HPA (normal tissue):	Group enriched (salivary gland, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in salivary gland, glandular cells in breast and squamous epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA040725
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, cervical cancer, head and neck cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040725

GENE INFORMATION
Gene name	CALML5 (HGNC Symbol)
Synonyms	CLSP
Description	Calmodulin-like 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p15.1
Chromosome location (bp)	5498697 - 5499555
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178372 (version 83.38)
Entrez gene	51806
UniProt	Q9NZT1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZT1
Antibodypedia	CALML5 antibodies

PROTEIN BROWSER

CALML5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALML5-001 ENSP00000369689 ENST00000380332	Q9NZT1 [Direct mapping] Calmodulin-like protein 5 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0007165 [signal transduction] GO:0008544 [epidermis development] GO:0070062 [extracellular exosome] Show all	146 aa 15.9 kDa	No	0