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CALML5

GENERAL INFORMATION

Gene name

 CALML5

Gene description

 Calmodulin-like 5

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (salivary gland, skin)
GTEx:Tissue enriched (skin)
FANTOM5:Tissue enriched (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in salivary gland, glandular cells in breast and squamous epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA040725
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (salivary gland, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 CALML5 (HGNC Symbol)

Synonyms

 CLSP

Description

 Calmodulin-like 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5498697 - 5499555

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178372 (version 83.38)

Entrez gene

 51806

UniProt

 Q9NZT1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZT1

Antibodypedia

 CALML5 antibodies

PROTEIN BROWSER
CALML5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CALML5-001
ENSP00000369689
ENST00000380332
Q9NZT1 [Direct mapping]
Calmodulin-like protein 5
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0007165 [signal transduction]
GO:0008544 [epidermis development]
GO:0070062 [extracellular exosome]
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 146 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.