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This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001739 [sex chromatin] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008284 [positive regulation of cell proliferation] GO:0010467 [gene expression] GO:0016571 [histone methylation] GO:0016574 [histone ubiquitination] GO:0031490 [chromatin DNA binding] GO:0032993 [protein-DNA complex] GO:0035064 [methylated histone binding] GO:0035098 [ESC/E(Z) complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0042054 [histone methyltransferase activity] GO:0043565 [sequence-specific DNA binding] GO:0045596 [negative regulation of cell differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046872 [metal ion binding]
Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
