Cell atlas - HYI - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HYI
Gene description	Hydroxypyruvate isomerase (putative)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (WM-115, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Additional location	In addition localized to the Golgi apparatus (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040092
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the Golgi apparatus.

Main location

Plasma membrane (approved), Cytosol (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA040092	A-431	Plasma membrane
HPA040092	A-431	Cytosol
HPA040092	U-2 OS	Plasma membrane	Intensity	Intensity
HPA040092	U-2 OS	Cytosol
HPA040092	U-251 MG	Golgi apparatus
		Plasma membrane
		Cytosol

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA040092	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. HYI is mostly expressed during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Plasma membrane

GENE INFORMATION
Gene name	HYI (HGNC Symbol)
Synonyms	HT036
Description	Hydroxypyruvate isomerase (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	43451003 - 43453989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178922 (version 83.38)
Entrez gene	81888
UniProt	Q5T013 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T013
Antibodypedia	HYI antibodies

PROTEIN BROWSER

HYI-001	HYI-002	HYI-004	HYI-005	HYI-006	HYI-008	HYI-009	HYI-201	HYI-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HYI-001 ENSP00000361507 ENST00000372430	J9JIE9 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		238 aa 26.1 kDa	No	0
HYI-002 ENSP00000361509 ENST00000372432	Q5T013 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0008903 [hydroxypyruvate isomerase activity] Show all	247 aa 26.9 kDa	No	0
HYI-004 ENSP00000361511 ENST00000372434	F6UJY1 [Direct mapping] Putative hydroxypyruvate isomerase Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		302 aa 33 kDa	No	0
HYI-005 ENSP00000361510 ENST00000372433	F6UJY9 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 23 kDa	No	0
HYI-006 ENSP00000428501 ENST00000487366	H0YB18 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.6 kDa	No	0
HYI-008 ENSP00000428803 ENST00000470662	H0YB70 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 20.6 kDa	No	0
HYI-009 ENSP00000428399 ENST00000486909	E7EWH8 [Direct mapping] Hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008903 [hydroxypyruvate isomerase activity] Show all	276 aa 30.3 kDa	No	0
HYI-201 ENSP00000361502 ENST00000372425	Q5T013 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0008903 [hydroxypyruvate isomerase activity] Show all	277 aa 30.4 kDa	No	0
HYI-202 ENSP00000461969 ENST00000583037	A0A0A0MTR5 [Direct mapping] Putative hydroxypyruvate isomerase Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		272 aa 29.5 kDa	No	0