Expression of HYI in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HYI

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HYI
Gene description	Hydroxypyruvate isomerase (putative)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, WM-115)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA040092
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), renal cancer (unfavourable), colorectal cancer (unfavourable), liver cancer (unfavourable) and breast cancer (favourable).
Urothelial cancer p<0.001 Renal cancer p<0.001 Colorectal cancer p<0.001 Liver cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040092

GENE INFORMATION
Gene name	HYI (HGNC Symbol)
Synonyms	HT036
Description	Hydroxypyruvate isomerase (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	43451003 - 43453989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178922 (version 83.38)
Entrez gene	81888
UniProt	Q5T013 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T013
Antibodypedia	HYI antibodies

PROTEIN BROWSER

HYI-001	HYI-002	HYI-004	HYI-005	HYI-006	HYI-008	HYI-009	HYI-201	HYI-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HYI-001 ENSP00000361507 ENST00000372430	J9JIE9 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		238 aa 26.1 kDa	No	0
HYI-002 ENSP00000361509 ENST00000372432	Q5T013 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0008903 [hydroxypyruvate isomerase activity] Show all	247 aa 26.9 kDa	No	0
HYI-004 ENSP00000361511 ENST00000372434	F6UJY1 [Direct mapping] Putative hydroxypyruvate isomerase Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		302 aa 33 kDa	No	0
HYI-005 ENSP00000361510 ENST00000372433	F6UJY9 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 23 kDa	No	0
HYI-006 ENSP00000428501 ENST00000487366	H0YB18 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.6 kDa	No	0
HYI-008 ENSP00000428803 ENST00000470662	H0YB70 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 20.6 kDa	No	0
HYI-009 ENSP00000428399 ENST00000486909	E7EWH8 [Direct mapping] Hydroxypyruvate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008903 [hydroxypyruvate isomerase activity] Show all	276 aa 30.3 kDa	No	0
HYI-201 ENSP00000361502 ENST00000372425	Q5T013 [Direct mapping] Putative hydroxypyruvate isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0008903 [hydroxypyruvate isomerase activity] Show all	277 aa 30.4 kDa	No	0
HYI-202 ENSP00000461969 ENST00000583037	A0A0A0MTR5 [Direct mapping] Putative hydroxypyruvate isomerase Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		272 aa 29.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.