Expression of LGALS7B in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LGALS7B

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LGALS7B
Gene description	Lectin, galactoside-binding, soluble, 7B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, melanoma)
HPA (cell line):	Cell line enriched (HaCaT)
HPA (normal tissue):	Tissue enhanced (breast, esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear and cytoplasmic staining in squamous epithelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA001549 , CAB025100
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001549	CAB025100

GENE INFORMATION
Gene name	LGALS7B (HGNC Symbol)
Synonyms	GAL7
Description	Lectin, galactoside-binding, soluble, 7B (HGNC Symbol)
Entrez gene summary	The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38789211 - 38791749
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178934 (version 83.38)
Entrez gene	653499
UniProt	P47929 (UniProt - Evidence at protein level)
neXtProt	NX_P47929
Antibodypedia	LGALS7B antibodies

PROTEIN BROWSER

LGALS7B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGALS7B-001 ENSP00000313571 ENST00000314980	P47929 [Direct mapping] Galectin-7 Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] Show all	136 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.