Cell atlas - FBXO34 - The Human Protein Atlas

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FBXO34

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FBXO34
Gene description	F-box protein 34
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052592
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052592	HeLa	Nuclear speckles
	HPA052592	MCF7	Nuclear speckles
	HPA052592	U-2 OS	Nuclear speckles
	HPA052592	U-2 OS	Cytosol

GENE INFORMATION
Gene name	FBXO34 (HGNC Symbol)
Synonyms	Fbx34, FLJ20725
Description	F-box protein 34 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	14
Cytoband	q22.3
Chromosome location (bp)	55271303 - 55361918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178974 (version 83.38)
Entrez gene	55030
UniProt	Q9NWN3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWN3
Antibodypedia	FBXO34 antibodies

PROTEIN BROWSER

FBXO34-001	FBXO34-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXO34-001 ENSP00000313159 ENST00000313833	Q9NWN3 [Direct mapping] F-box only protein 34 A0A024R653 [Target identity:100%; Query identity:100%] F-box protein 34, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	711 aa 78.7 kDa	No	0
FBXO34-201 ENSP00000394117 ENST00000440021	Q9NWN3 [Direct mapping] F-box only protein 34 A0A024R653 [Target identity:100%; Query identity:100%] F-box protein 34, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	711 aa 78.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.