Expression of FBXO34 in cancer - Summary - The Human Protein Atlas

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FBXO34

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FBXO34
Gene description	F-box protein 34
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including smooth muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA052592
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052592

GENE INFORMATION
Gene name	FBXO34 (HGNC Symbol)
Synonyms	Fbx34, FLJ20725
Description	F-box protein 34 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	14
Cytoband	q22.3
Chromosome location (bp)	55271303 - 55361918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178974 (version 83.38)
Entrez gene	55030
UniProt	Q9NWN3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWN3
Antibodypedia	FBXO34 antibodies

PROTEIN BROWSER

FBXO34-001	FBXO34-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXO34-001 ENSP00000313159 ENST00000313833	Q9NWN3 [Direct mapping] F-box only protein 34 A0A024R653 [Target identity:100%; Query identity:100%] F-box protein 34, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	711 aa 78.7 kDa	No	0
FBXO34-201 ENSP00000394117 ENST00000440021	Q9NWN3 [Direct mapping] F-box only protein 34 A0A024R653 [Target identity:100%; Query identity:100%] F-box protein 34, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	711 aa 78.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.