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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Method

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Method

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Searches

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Cell line

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PTPN11
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PTPN11

Gene description

Protein tyrosine phosphatase, non-receptor type 11

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB005377
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
N/A
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
N/A
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
N/A
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PTPN11 (HGNC Symbol)

Synonyms

BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2

Description

Protein tyrosine phosphatase, non-receptor type 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

q24.13

Chromosome location (bp)

112418351 - 112509913

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179295 (version 83.38)

Entrez gene

5781

UniProt

Q06124 (UniProt - Evidence at protein level)

neXtProt

NX_Q06124

Antibodypedia

PTPN11 antibodies

PROTEIN BROWSER

PTPN11-001
PTPN11-002
PTPN11-004
PTPN11-005
PTPN11-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN11-001
ENSP00000340944
ENST00000351677
Q06124 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000187 [activation of MAPK activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006629 [lipid metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019904 [protein domain specific binding]
GO:0021697 [cerebellar cortex formation]
GO:0030220 [platelet formation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031295 [T cell costimulation]
GO:0031748 [D1 dopamine receptor binding]
GO:0032528 [microvillus organization]
GO:0033277 [abortive mitotic cell cycle]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0035264 [multicellular organism growth]
GO:0035265 [organ growth]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035855 [megakaryocyte development]
GO:0036302 [atrioventricular canal development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042445 [hormone metabolic process]
GO:0042593 [glucose homeostasis]
GO:0043234 [protein complex]
GO:0043274 [phospholipase binding]
GO:0043560 [insulin receptor substrate binding]
GO:0045087 [innate immune response]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046676 [negative regulation of insulin secretion]
GO:0046825 [regulation of protein export from nucleus]
GO:0046887 [positive regulation of hormone secretion]
GO:0046888 [negative regulation of hormone secretion]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048609 [multicellular organismal reproductive process]
GO:0048806 [genitalia development]
GO:0048839 [inner ear development]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050900 [leukocyte migration]
GO:0051428 [peptide hormone receptor binding]
GO:0051463 [negative regulation of cortisol secretion]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060125 [negative regulation of growth hormone secretion]
GO:0060325 [face morphogenesis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0061582 [intestinal epithelial cell migration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
593 aa
68 kDa
No 0
PTPN11-002
ENSP00000376376
ENST00000392597
Q06124 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031295 [T cell costimulation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036302 [atrioventricular canal development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048806 [genitalia development]
GO:0048839 [inner ear development]
GO:0050900 [leukocyte migration]
GO:0060325 [face morphogenesis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
460 aa
52.8 kDa
No 0
PTPN11-004
ENSP00000437013
ENST00000530818
H0YF12 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 11
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
108 aa
12.2 kDa
No 0
PTPN11-005
ENSP00000489541
ENST00000635652
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
196 aa
22.7 kDa
No 0
PTPN11-006
ENSP00000489597
ENST00000635625
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
597 aa
68.4 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.