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ARID3B

GENERAL INFORMATION

Gene name

 ARID3B

Gene description

 AT rich interactive domain 3B (BRIGHT-like)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (NTERA-2)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050320
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050320

GENE INFORMATION

Gene name

 ARID3B (HGNC Symbol)

Synonyms

 BDP, DRIL2

Description

 AT rich interactive domain 3B (BRIGHT-like) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q24.1

Chromosome location (bp)

 74541177 - 74598131

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179361 (version 83.38)

Entrez gene

 10620

UniProt

 Q8IVW6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IVW6

Antibodypedia

 ARID3B antibodies

PROTEIN BROWSER
ARID3B-001
ARID3B-004
ARID3B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARID3B-001
ENSP00000343126
ENST00000346246
Q8IVW6 [Direct mapping]
AT-rich interactive domain-containing protein 3B
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008150 [biological_process]
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 560 aa
60.6 kDa 		No 0
ARID3B-004
ENSP00000455668
ENST00000566147
H3BQ92 [Direct mapping]
AT-rich interactive domain-containing protein 3B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
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 138 aa
14.9 kDa 		No 0
ARID3B-201
ENSP00000477878
ENST00000622429
Q8IVW6 [Direct mapping]
AT-rich interactive domain-containing protein 3B
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 561 aa
60.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.