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Several adenocarcinomas of lung showed moderate to strong cytoplasmic immunoreactivity. Few gliomas, breast, cervical and skin cancers showed weak to moderate positivity. Moderate nuclear staining was shown in few melanomas. Remaining cancer tissues were weakly stained or generally negative.
GENE INFORMATION
Gene name
GPC5
Synonyms
Description
Glypican 5 (HGNC Symbol)
Entrez gene summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]