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ALOX12B

GENERAL INFORMATION

Gene name

 ALOX12B

Gene description

 Arachidonate 12-lipoxygenase, 12R type

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, melanoma)
HPA (cell line):Cell line enhanced (HEK93, hTCEpi)
HPA (normal tissue):Group enriched (skin, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in keratinized layer of epidermis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA024002
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024002

GENE INFORMATION

Gene name

 ALOX12B (HGNC Symbol)

Synonyms

 12R-LOX

Description

 Arachidonate 12-lipoxygenase, 12R type (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8072636 - 8087703

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179477 (version 83.38)

Entrez gene

 242

UniProt

 O75342 (UniProt - Evidence at protein level)

neXtProt

 NX_O75342

Antibodypedia

 ALOX12B antibodies

PROTEIN BROWSER
ALOX12B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALOX12B-001
ENSP00000315167
ENST00000319144
O75342 [Direct mapping]
Arachidonate 12-lipoxygenase, 12R-type
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006665 [sphingolipid metabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043651 [linoleic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046513 [ceramide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0061436 [establishment of skin barrier]
GO:0070257 [positive regulation of mucus secretion]
GO:1990136 [linoleate 9S-lipoxygenase activity]
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 701 aa
80.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.