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Arachidonate 12-lipoxygenase, 12R type (HGNC Symbol)
Entrez gene summary
This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity] GO:0004052 [arachidonate 12-lipoxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006497 [protein lipidation] GO:0006665 [sphingolipid metabolic process] GO:0010628 [positive regulation of gene expression] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019372 [lipoxygenase pathway] GO:0043410 [positive regulation of MAPK cascade] GO:0043651 [linoleic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0046872 [metal ion binding] GO:0051122 [hepoxilin biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0061436 [establishment of skin barrier] GO:0070257 [positive regulation of mucus secretion] GO:1990136 [linoleate 9S-lipoxygenase activity]
