Cell atlas - APOBEC3B - The Human Protein Atlas

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APOBEC3B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	APOBEC3B
Gene description	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (A-431, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA056980 , HPA066719
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056980	A-431	Nucleus
	HPA056980	A549	Nucleoplasm
	HPA056980	U-2 OS	No staining
	HPA066719	A-431	Nucleoplasm
	HPA066719	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	APOBEC3B (HGNC Symbol)
Synonyms	FLJ21201, PHRBNL
Description	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B (HGNC Symbol)
Entrez gene summary	This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	38982347 - 38992804
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179750 (version 83.38)
Entrez gene	9582
UniProt	Q9UH17 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH17
Antibodypedia	APOBEC3B antibodies

PROTEIN BROWSER

APOBEC3B-001	APOBEC3B-002	APOBEC3B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOBEC3B-001 ENSP00000327459 ENST00000333467	Q9UH17 [Direct mapping] DNA dC->dU-editing enzyme APOBEC-3B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0010529 [negative regulation of transposition] GO:0016787 [hydrolase activity] GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0047844 [deoxycytidine deaminase activity] GO:0051607 [defense response to virus] Show all	382 aa 45.9 kDa	No	0
APOBEC3B-002 ENSP00000385060 ENST00000402182	B0QYD3 [Direct mapping] DNA dC->dU-editing enzyme APOBEC-3B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016787 [hydrolase activity] GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines] Show all	490 aa 57.2 kDa	No	0
APOBEC3B-003 ENSP00000385068 ENST00000407298	Q9UH17 [Direct mapping] DNA dC->dU-editing enzyme APOBEC-3B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0010529 [negative regulation of transposition] GO:0016787 [hydrolase activity] GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0047844 [deoxycytidine deaminase activity] GO:0051607 [defense response to virus] Show all	357 aa 43.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.