Expression of GIPC3 in cancer - Summary

GENERAL INFORMATION
Gene name	GIPC3
Gene description	GIPC PDZ domain containing family, member 3
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HeLa, HMC-1, THP-1, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most tissues with additional cytoplasmic expression in some tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA061258
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA061258

GENE INFORMATION
Gene name	GIPC3 (HGNC Symbol)
Synonyms	C19orf64, DFNB15, DFNB72, DFNB95
Description	GIPC PDZ domain containing family, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2011]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3585553 - 3593541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179855 (version 83.38)
Entrez gene	126326
UniProt	Q8TF64 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF64
Antibodypedia	GIPC3 antibodies

PROTEIN BROWSER

GIPC3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GIPC3-001 ENSP00000319254 ENST00000322315	Q8TF64 [Direct mapping] PDZ domain-containing protein GIPC3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	312 aa 34 kDa	No	0