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TSHZ1

GENERAL INFORMATION

Gene name

 TSHZ1

Gene description

 Teashirt zinc finger homeobox 1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006982
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006982

GENE INFORMATION

Gene name

 TSHZ1 (HGNC Symbol)

Synonyms

 NY-CO-33, SDCCAG33, TSH1

Description

 Teashirt zinc finger homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]

Chromosome

 18

Cytoband

 q22.3

Chromosome location (bp)

 75210755 - 75289950

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179981 (version 83.38)

Entrez gene

 10194

UniProt

 Q6ZSZ6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6ZSZ6

Antibodypedia

 TSHZ1 antibodies

PROTEIN BROWSER
TSHZ1-001
TSHZ1-002
TSHZ1-003
TSHZ1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSHZ1-001
ENSP00000323584
ENST00000322038
Q6ZSZ6 [Direct mapping]
Teashirt homolog 1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 1032 aa
112.7 kDa 		No 0
TSHZ1-002
ENSP00000453834
ENST00000560918
H0YN23 [Direct mapping]
Teashirt homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0010468 [regulation of gene expression]
GO:0046872 [metal ion binding]
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 277 aa
30.3 kDa 		No 0
TSHZ1-003
ENSP00000452718
ENST00000560661
H0YKA1 [Direct mapping]
Teashirt homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0010468 [regulation of gene expression]
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 78 aa
8.5 kDa 		No 0
TSHZ1-005
ENSP00000464391
ENST00000580243
Q6ZSZ6 [Direct mapping]
Teashirt homolog 1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009952 [anterior/posterior pattern specification]
GO:0042474 [middle ear morphogenesis]
GO:0046872 [metal ion binding]
GO:0060023 [soft palate development]
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 1077 aa
117.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.