Expression of MYLPF in cancer - Summary - The Human Protein Atlas

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MYLPF

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MYLPF
Gene description	Myosin light chain, phosphorylatable, fast skeletal muscle
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA039262
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039262

GENE INFORMATION
Gene name	MYLPF (HGNC Symbol)
Synonyms	HUMMLC2B, MRLC2, MYL11
Description	Myosin light chain, phosphorylatable, fast skeletal muscle (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30370934 - 30377991
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180209 (version 83.38)
Entrez gene	29895
UniProt	Q96A32 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96A32
Antibodypedia	MYLPF antibodies

PROTEIN BROWSER

MYLPF-001	MYLPF-002	MYLPF-003	MYLPF-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYLPF-001 ENSP00000325239 ENST00000322861	Q96A32 [Direct mapping] Myosin regulatory light chain 2, skeletal muscle isoform A0A024QZG6 [Target identity:100%; Query identity:100%] Fast skeletal myosin light chain 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005765 [lysosomal membrane] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007519 [skeletal muscle tissue development] GO:0008307 [structural constituent of muscle] Show all	169 aa 19 kDa	No	0
MYLPF-002 ENSP00000454444 ENST00000563718	H3BML9 [Direct mapping] Myosin regulatory light chain 2, skeletal muscle isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	118 aa 13.2 kDa	No	0
MYLPF-003 ENSP00000455356 ENST00000566955	H3BPK4 [Direct mapping] Myosin regulatory light chain 2, skeletal muscle isoform Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	199 aa 22 kDa	No	0
MYLPF-005 ENSP00000454694 ENST00000568749	H3BN54 [Direct mapping] Myosin regulatory light chain 2, skeletal muscle isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	135 aa 15.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.