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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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F2
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

F2

Gene description

Coagulation factor II (thrombin)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct expression in a subset of hepatocytes and positivity in plasma.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 4 antibodies.
HPA051476 , HPA054698 , CAB016780 , CAB018650
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

F2

Synonyms

Description

Coagulation factor II (thrombin) (HGNC Symbol)

Entrez gene summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

46719180 - 46739506

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180210 (version 83.38)

Entrez gene

2147

UniProt

P00734 (UniProt - Evidence at protein level)

neXtProt

NX_P00734

Antibodypedia

F2 antibodies

PROTEIN BROWSER

F2-001
F2-003
F2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F2-001
ENSP00000308541
ENST00000311907
P00734 [Direct mapping]
Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006953 [acute-phase response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008083 [growth factor activity]
GO:0008233 [peptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010468 [regulation of gene expression]
GO:0010544 [negative regulation of platelet activation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014854 [response to inactivity]
GO:0017187 [peptidyl-glutamic acid carboxylation]
GO:0030168 [platelet activation]
GO:0030193 [regulation of blood coagulation]
GO:0030194 [positive regulation of blood coagulation]
GO:0030307 [positive regulation of cell growth]
GO:0031012 [extracellular matrix]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0042730 [fibrinolysis]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045861 [negative regulation of proteolysis]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050900 [leukocyte migration]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051918 [negative regulation of fibrinolysis]
GO:0070053 [thrombospondin receptor activity]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:0072562 [blood microparticle]
GO:1900738 [positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
622 aa
70 kDa
Yes 0
F2-003
ENSP00000387413
ENST00000442468
C9JV37 [Direct mapping]
Prothrombin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
Show all
324 aa
35.9 kDa
No 0
F2-005
ENSP00000433907
ENST00000530231
E9PIT3 [Direct mapping]
Prothrombin
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
Show all
583 aa
65.4 kDa
Yes 0

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