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PRKRA

GENERAL INFORMATION

Gene name

 PRKRA

Gene description

 Protein kinase, interferon-inducible double stranded RNA dependent activator

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA034996 , HPA034997 , CAB004648
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and testis cancer (favourable).
Liver cancer p<0.001
Testis cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034996
HPA034997
CAB004648

GENE INFORMATION

Gene name

 PRKRA (HGNC Symbol)

Synonyms

 DYT16, HSD14, PACT, RAX

Description

 Protein kinase, interferon-inducible double stranded RNA dependent activator (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Chromosome

 2

Cytoband

 q31.2

Chromosome location (bp)

 178431414 - 178451512

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180228 (version 83.38)

Entrez gene

 8575

UniProt

 O75569 (UniProt - Evidence at protein level)

neXtProt

 NX_O75569

Antibodypedia

 PRKRA antibodies

PROTEIN BROWSER
PRKRA-001
PRKRA-003
PRKRA-008
PRKRA-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKRA-001
ENSP00000318176
ENST00000325748
O75569 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0008047 [enzyme activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0034599 [cellular response to oxidative stress]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0042473 [outer ear morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048705 [skeletal system morphogenesis]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
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 313 aa
34.4 kDa 		No 0
PRKRA-003
ENSP00000430604
ENST00000487082
O75569 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0008047 [enzyme activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
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 288 aa
31.6 kDa 		No 0
PRKRA-008
ENSP00000408668
ENST00000457633
C9JMM3 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 109 aa
12 kDa 		No 0
PRKRA-009
ENSP00000393883
ENST00000432031
O75569 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0008047 [enzyme activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 302 aa
33.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.