Expression of SLC9A4 in cancer - Summary - The Human Protein Atlas

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SLC9A4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC9A4
Gene description	Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, RT4)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Nuclear staining was viewed as off target and disregarded.
Reliability score	Approved based on 1 antibody. HPA036096
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036096

GENE INFORMATION
Gene name	SLC9A4 (HGNC Symbol)
Synonyms	NHE4
Description	Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q12.1
Chromosome location (bp)	102473303 - 102533972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180251 (version 83.38)
Entrez gene	389015
UniProt	Q6AI14 (UniProt - Evidence at protein level)
neXtProt	NX_Q6AI14
Antibodypedia	SLC9A4 antibodies

PROTEIN BROWSER

SLC9A4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A4-001 ENSP00000295269 ENST00000295269	Q6AI14 [Direct mapping] Sodium/hydrogen exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001696 [gastric acid secretion] GO:0002064 [epithelial cell development] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	798 aa 89.8 kDa	Yes	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.