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SLC9A4

GENERAL INFORMATION

Gene name

 SLC9A4

Gene description

 Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (stomach)
GTEx:Tissue enriched (stomach)
FANTOM5:Tissue enhanced (gallbladder, kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in stomach.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Nuclear staining was viewed as off target and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA036096
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, kidney)

GENE INFORMATION

Gene name

 SLC9A4 (HGNC Symbol)

Synonyms

 NHE4

Description

 Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q12.1

Chromosome location (bp)

 102473303 - 102533972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180251 (version 83.38)

Entrez gene

 389015

UniProt

 Q6AI14 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6AI14

Antibodypedia

 SLC9A4 antibodies

PROTEIN BROWSER
SLC9A4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC9A4-001
ENSP00000295269
ENST00000295269
Q6AI14 [Direct mapping]
Sodium/hydrogen exchanger 4
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0001696 [gastric acid secretion]
GO:0002064 [epithelial cell development]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
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 798 aa
89.8 kDa 		Yes >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.