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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ALX1
  • TISSUE

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    CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ALX1

Gene description

ALX homeobox 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enhanced (HEK93, HUVEC TERT2, SK-MEL-30, THP-1, WM-115)
HPA (normal tissue):Tissue enhanced (epididymis, kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 2 antibodies.
HPA001598 , HPA018905
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001598
HPA018905

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most malignant tissues displayed weak to moderate nuclear immunoreactivity, often accompanied with faint cytoplasmic staining.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Moderate to strong nuclear and cytoplasmic positivity was observed in a majority of cancer tissues. Lymphomas, testicular, urothelial and several lung cancers were negative.

GENE INFORMATION

Gene name

ALX1 (HGNC Symbol)

Synonyms

CART1

Description

ALX homeobox 1 (HGNC Symbol)

Entrez gene summary

The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q21.31

Chromosome location (bp)

85280107 - 85301784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180318 (version 83.38)

Entrez gene

8092

UniProt

Q15699 (UniProt - Evidence at protein level)

neXtProt

NX_Q15699

Antibodypedia

ALX1 antibodies

PROTEIN BROWSER

ALX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALX1-001
ENSP00000315417
ENST00000316824
Q15699 [Direct mapping]
ALX homeobox protein 1
V9HWA7 [Target identity:100%; Query identity:100%]
Cartilage paired-class homeoprotein 1; Epididymis luminal protein 23
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001502 [cartilage condensation]
GO:0001843 [neural tube closure]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0009952 [anterior/posterior pattern specification]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0014031 [mesenchymal cell development]
GO:0030326 [embryonic limb morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0060021 [palate development]
Show all
326 aa
37 kDa
No 0

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