We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
PAK2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PAK2

Gene description

P21 protein (Cdc42/Rac)-activated kinase 2

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in immune tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB007794
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable) and prostate cancer (unfavourable).
Pancreatic cancer p<0.001
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB007794

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant tissues showed weak to moderate cytoplasmic staining. Malignant lymphomas, ovarian and colorectal cancers displayed moderate to strong immunoreactivity.

GENE INFORMATION

Gene name

PAK2 (HGNC Symbol)

Synonyms

PAK65, PAKgamma

Description

P21 protein (Cdc42/Rac)-activated kinase 2 (HGNC Symbol)

Entrez gene summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q29

Chromosome location (bp)

196739857 - 196832647

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180370 (version 83.38)

Entrez gene

5062

UniProt

Q13177 (UniProt - Evidence at protein level)

neXtProt

NX_Q13177

Antibodypedia

PAK2 antibodies

PROTEIN BROWSER

PAK2-001
PAK2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAK2-001
ENSP00000314067
ENST00000327134
Q13177 [Direct mapping]
Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007411 [axon guidance]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0032147 [activation of protein kinase activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0060996 [dendritic spine development]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0071407 [cellular response to organic cyclic compound]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001271 [negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
524 aa
58 kDa
No 0
PAK2-004
ENSP00000402927
ENST00000426668
H7C1X3 [Direct mapping]
Serine/threonine-protein kinase PAK 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
221 aa
24.4 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.