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P21 protein (Cdc42/Rac)-activated kinase 2 (HGNC Symbol)
Entrez gene summary
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Q13177 [Direct mapping] Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0018105 [peptidyl-serine phosphorylation] GO:0019901 [protein kinase binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030036 [actin cytoskeleton organization] GO:0030296 [protein tyrosine kinase activator activity] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031295 [T cell costimulation] GO:0032147 [activation of protein kinase activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0040008 [regulation of growth] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043408 [regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048365 [Rac GTPase binding] GO:0048471 [perinuclear region of cytoplasm] GO:0050690 [regulation of defense response to virus by virus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050852 [T cell receptor signaling pathway] GO:0060996 [dendritic spine development] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0071407 [cellular response to organic cyclic compound] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] GO:2001271 [negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]