Expression of GAS1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GAS1
Gene description	Growth arrest-specific 1
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AN3-CA, BJ hTERT+, RH-30)
HPA (normal tissue):	Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Abundant cytoplasmic expression in glandular cells with a few cases of membranous expression in male and female reproductive tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA066902 , CAB024164
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable), renal cancer (unfavourable), colorectal cancer (unfavourable) and stomach cancer (unfavourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Colorectal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA066902	CAB024164

GENE INFORMATION
Gene name	GAS1
Synonyms
Description	Growth arrest-specific 1 (HGNC Symbol)
Entrez gene summary	Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	86944363 - 86947189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180447 (version 83.38)
Entrez gene	2619
UniProt	P54826 (UniProt - Evidence at transcript level)
neXtProt	NX_P54826
Antibodypedia	GAS1 antibodies

PROTEIN BROWSER

GAS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAS1-001 ENSP00000298743 ENST00000298743	P54826 [Direct mapping] Growth arrest-specific protein 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007050 [cell cycle arrest] GO:0008589 [regulation of smoothened signaling pathway] GO:0010955 [negative regulation of protein processing] GO:0016021 [integral component of membrane] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0042981 [regulation of apoptotic process] GO:0045165 [cell fate commitment] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046658 [anchored component of plasma membrane] GO:0048589 [developmental growth] GO:0060628 [regulation of ER to Golgi vesicle-mediated transport] Show all	345 aa 35.7 kDa	Yes	0