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GAS1

GENERAL INFORMATION

Gene name

 GAS1

Gene description

 Growth arrest-specific 1

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (endometrium)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (endometrium)

Protein evidence

 Evidence at protein level

Protein expression

 Abundant cytoplasmic expression in glandular cells with a few cases of membranous expression in male and female reproductive tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA066902 , CAB024164
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)

GENE INFORMATION

Gene name

 GAS1

Synonyms

Description

 Growth arrest-specific 1 (HGNC Symbol)

Entrez gene summary

 Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q21.33

Chromosome location (bp)

 86944363 - 86947189

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180447 (version 83.38)

Entrez gene

 2619

UniProt

 P54826 (UniProt - Evidence at transcript level)

neXtProt

 NX_P54826

Antibodypedia

 GAS1 antibodies

PROTEIN BROWSER
GAS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAS1-001
ENSP00000298743
ENST00000298743
P54826 [Direct mapping]
Growth arrest-specific protein 1
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007050 [cell cycle arrest]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010955 [negative regulation of protein processing]
GO:0016021 [integral component of membrane]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0045165 [cell fate commitment]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046658 [anchored component of plasma membrane]
GO:0048589 [developmental growth]
GO:0060628 [regulation of ER to Golgi vesicle-mediated transport]
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 345 aa
35.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.