Expression of S1PR5 in cancer - Summary

GENERAL INFORMATION
Gene name	S1PR5
Gene description	Sphingosine-1-phosphate receptor 5
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, lung cancer, urothelial cancer)
HPA (cell line):	Cell line enhanced (HaCaT, RT4, T-47d, U-2 OS)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in processes in CNS and in subsets of immune cells in several tissues including skin and lymphoid organs.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA029683
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, lung cancer, urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029683

GENE INFORMATION
Gene name	S1PR5 (HGNC Symbol)
Synonyms	Edg-8, EDG8
Description	Sphingosine-1-phosphate receptor 5 (HGNC Symbol)
Entrez gene summary	The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10512742 - 10517931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180739 (version 83.38)
Entrez gene	53637
UniProt	Q9H228 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H228
Antibodypedia	S1PR5 antibodies

PROTEIN BROWSER

S1PR5-001	S1PR5-004	S1PR5-007	S1PR5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S1PR5-001 ENSP00000328472 ENST00000333430	Q9H228 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] GO:0045664 [regulation of neuron differentiation] Show all	398 aa 41.8 kDa	No	7
S1PR5-004 ENSP00000416915 ENST00000439028	Q9H228 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	398 aa 41.8 kDa	No	7
S1PR5-007 ENSP00000464884 ENST00000590601	K7EIT5 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	75 aa 8.1 kDa	No	0
S1PR5-201 ENSP00000481239 ENST00000617721	A0A087WXR8 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	254 aa 26.7 kDa	No	3