Tissue expression of S1PR5 - Summary - The Human Protein Atlas

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S1PR5

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	S1PR5
Gene description	Sphingosine-1-phosphate receptor 5
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, skin)
GTEx:	Tissue enhanced (hippocampus)
FANTOM5:	Tissue enhanced (brain, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in processes in CNS and in subsets of immune cells in several tissues including skin and lymphoid organs.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA029683
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION
Gene name	S1PR5 (HGNC Symbol)
Synonyms	Edg-8, EDG8
Description	Sphingosine-1-phosphate receptor 5 (HGNC Symbol)
Entrez gene summary	The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10512742 - 10517931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180739 (version 83.38)
Entrez gene	53637
UniProt	Q9H228 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H228
Antibodypedia	S1PR5 antibodies

PROTEIN BROWSER

S1PR5-001	S1PR5-004	S1PR5-007	S1PR5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S1PR5-001 ENSP00000328472 ENST00000333430	Q9H228 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] GO:0045664 [regulation of neuron differentiation] Show all	398 aa 41.8 kDa	No	7
S1PR5-004 ENSP00000416915 ENST00000439028	Q9H228 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	398 aa 41.8 kDa	No	7
S1PR5-007 ENSP00000464884 ENST00000590601	K7EIT5 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	75 aa 8.1 kDa	No	0
S1PR5-201 ENSP00000481239 ENST00000617721	A0A087WXR8 [Direct mapping] Sphingosine 1-phosphate receptor 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	254 aa 26.7 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.