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ARSJ

GENERAL INFORMATION

Gene name

 ARSJ

Gene description

 Arylsulfatase family, member J

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (TIME)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA036481 , HPA036482
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036481
HPA036482

GENE INFORMATION

Gene name

 ARSJ (HGNC Symbol)

Synonyms

 FLJ23548

Description

 Arylsulfatase family, member J (HGNC Symbol)

Entrez gene summary

 Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

Chromosome

 4

Cytoband

 q26

Chromosome location (bp)

 113900284 - 113979727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180801 (version 83.38)

Entrez gene

 79642

UniProt

 Q5FYB0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q5FYB0

Antibodypedia

 ARSJ antibodies

PROTEIN BROWSER
ARSJ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARSJ-001
ENSP00000320219
ENST00000315366
Q5FYB0 [Direct mapping]
Arylsulfatase J
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004065 [arylsulfatase activity]
GO:0005576 [extracellular region]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008152 [metabolic process]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
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 599 aa
67.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.