Expression of BHLHE22 in cancer - Summary - The Human Protein Atlas

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BHLHE22

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BHLHE22
Gene description	Basic helix-loop-helix family, member e22
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (THP-1)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear expression in cells in molecular layer of cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 3 antibodies. HPA064128 , HPA064872 , HPA067500
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA064128	HPA064872	HPA067500

GENE INFORMATION
Gene name	BHLHE22 (HGNC Symbol)
Synonyms	Beta3, BHLHB5, bHLHe22, CAGL85, TNRC20
Description	Basic helix-loop-helix family, member e22 (HGNC Symbol)
Entrez gene summary	BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM, Jul 2010]
Chromosome	8
Cytoband	q12.3
Chromosome location (bp)	64580367 - 64583628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180828 (version 83.38)
Entrez gene	27319
UniProt	Q8NFJ8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NFJ8
Antibodypedia	BHLHE22 antibodies

PROTEIN BROWSER

BHLHE22-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BHLHE22-001 ENSP00000318799 ENST00000321870	Q8NFJ8 [Direct mapping] Class E basic helix-loop-helix protein 22 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	381 aa 37 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.