Tissue expression of BHLHE22 - Summary - The Human Protein Atlas

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BHLHE22

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BHLHE22
Gene description	Basic helix-loop-helix family, member e22
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Group enriched (cerebellum, hippocampus)
FANTOM5:	Group enriched (cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Selective nuclear expression in cells in molecular layer of cerebellum.

DATA RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 3 antibodies. HPA064128 , HPA064872 , HPA067500
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, hippocampus)

GENE INFORMATION
Gene name	BHLHE22 (HGNC Symbol)
Synonyms	Beta3, BHLHB5, bHLHe22, CAGL85, TNRC20
Description	Basic helix-loop-helix family, member e22 (HGNC Symbol)
Entrez gene summary	BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM, Jul 2010]
Chromosome	8
Cytoband	q12.3
Chromosome location (bp)	64580367 - 64583628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180828 (version 83.38)
Entrez gene	27319
UniProt	Q8NFJ8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NFJ8
Antibodypedia	BHLHE22 antibodies

PROTEIN BROWSER

BHLHE22-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BHLHE22-001 ENSP00000318799 ENST00000321870	Q8NFJ8 [Direct mapping] Class E basic helix-loop-helix protein 22 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	381 aa 37 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.