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GREM2

GENERAL INFORMATION

Gene name

 GREM2

Gene description

 Gremlin 2, DAN family BMP antagonist

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BJ, BJ hTERT+, U-138 MG, U-87 MG)
HPA (normal tissue):Tissue enhanced (gallbladder, parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues with additional plasma positivity.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB009920
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009920

GENE INFORMATION

Gene name

 GREM2 (HGNC Symbol)

Synonyms

 CKTSF1B2, DAND3, FLJ21195, Prdc

Description

 Gremlin 2, DAN family BMP antagonist (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 240489573 - 240612149

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180875 (version 83.38)

Entrez gene

 64388

UniProt

 Q9H772 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9H772

Antibodypedia

 GREM2 antibodies

PROTEIN BROWSER
GREM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GREM2-001
ENSP00000318650
ENST00000318160
Q9H772 [Direct mapping]
Gremlin-2
A0A024R3Y1 [Target identity:100%; Query identity:100%]
Gremlin
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0008201 [heparin binding]
GO:0010172 [embryonic body morphogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030509 [BMP signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0036122 [BMP binding]
GO:0038098 [sequestering of BMP from receptor via BMP binding]
GO:0042803 [protein homodimerization activity]
GO:0060300 [regulation of cytokine activity]
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 168 aa
19.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.