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GREM2

GENERAL INFORMATION

Gene name

 GREM2

Gene description

 Gremlin 2, DAN family BMP antagonist

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder, parathyroid gland)
GTEx:Mixed
FANTOM5:Tissue enriched (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues with additional plasma positivity.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB009920
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (gallbladder)

GENE INFORMATION

Gene name

 GREM2 (HGNC Symbol)

Synonyms

 CKTSF1B2, DAND3, FLJ21195, Prdc

Description

 Gremlin 2, DAN family BMP antagonist (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 240489573 - 240612149

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180875 (version 83.38)

Entrez gene

 64388

UniProt

 Q9H772 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9H772

Antibodypedia

 GREM2 antibodies

PROTEIN BROWSER
GREM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GREM2-001
ENSP00000318650
ENST00000318160
Q9H772 [Direct mapping]
Gremlin-2
A0A024R3Y1 [Target identity:100%; Query identity:100%]
Gremlin
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0008201 [heparin binding]
GO:0010172 [embryonic body morphogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030509 [BMP signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0036122 [BMP binding]
GO:0038098 [sequestering of BMP from receptor via BMP binding]
GO:0042803 [protein homodimerization activity]
GO:0060300 [regulation of cytokine activity]
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 168 aa
19.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.