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Most cancer tissues displayed moderate to strong cytoplasmic and membranous positivity. Several cases of renal cancers, gliomas and lymphomas were weakly stained or negative.
Most cancer tissues displayed weak to moderate cytoplasmic and membranous positivity.
GENE INFORMATION
Gene name
SCRIB (HGNC Symbol)
Synonyms
KIAA0147, SCRB1, Vartul
Description
Scribbled planar cell polarity protein (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)