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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SCRIB

Gene description

Scribbled planar cell polarity protein

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA023557 , CAB015463 , CAB022081
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA023557
CAB015463
CAB022081

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong cytoplasmic and membranous positivity. Several cases of renal cancers, gliomas and lymphomas were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong membranous positivity. Lymphomas, renal and hepatocellular carcinomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed weak to moderate cytoplasmic and membranous positivity.

GENE INFORMATION

Gene name

SCRIB (HGNC Symbol)

Synonyms

KIAA0147, SCRB1, Vartul

Description

Scribbled planar cell polarity protein (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

8

Cytoband

q24.3

Chromosome location (bp)

143790920 - 143815379

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180900 (version 83.38)

Entrez gene

23513

UniProt

Q14160 (UniProt - Evidence at protein level)

neXtProt

NX_Q14160

Antibodypedia

SCRIB antibodies

PROTEIN BROWSER

SCRIB-001
SCRIB-002
SCRIB-003
SCRIB-004
SCRIB-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCRIB-001
ENSP00000322938
ENST00000320476
Q14160 [Direct mapping]
Protein scribble homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0001921 [positive regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0031252 [cell leading edge]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0042734 [presynaptic membrane]
GO:0043065 [positive regulation of apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0050918 [positive chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060603 [mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0090630 [activation of GTPase activity]
Show all
1630 aa
174.9 kDa
No 0
SCRIB-002
ENSP00000349486
ENST00000356994
Q14160 [Direct mapping]
Protein scribble homolog
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0001921 [positive regulation of receptor recycling]
GO:0002093 [auditory receptor cell morphogenesis]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0008105 [asymmetric protein localization]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0016080 [synaptic vesicle targeting]
GO:0016323 [basolateral plasma membrane]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0021747 [cochlear nucleus development]
GO:0030027 [lamellipodium]
GO:0031252 [cell leading edge]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0035748 [myelin sheath abaxonal region]
GO:0042060 [wound healing]
GO:0042734 [presynaptic membrane]
GO:0043065 [positive regulation of apoptotic process]
GO:0043615 [astrocyte cell migration]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050918 [positive chemotaxis]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060603 [mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0090630 [activation of GTPase activity]
Show all
1655 aa
177.7 kDa
No 0
SCRIB-003
ENSP00000366756
ENST00000377533
Q14160 [Direct mapping]
Protein scribble homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0001921 [positive regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0031252 [cell leading edge]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0042734 [presynaptic membrane]
GO:0043065 [positive regulation of apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0050918 [positive chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060603 [mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0090630 [activation of GTPase activity]
Show all
1549 aa
165.3 kDa
No 0
SCRIB-004
ENSP00000431519
ENST00000526832
H0YCG0 [Direct mapping]
Protein scribble homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
650 aa
68.3 kDa
No 0
SCRIB-007
ENSP00000433546
ENST00000531942
H0YDF9 [Direct mapping]
Protein scribble homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
140 aa
14.9 kDa
No 0

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