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SCRIB

GENERAL INFORMATION

Gene name

 SCRIB

Gene description

 Scribbled planar cell polarity protein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA023557 , CAB015463 , CAB022081
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SCRIB (HGNC Symbol)

Synonyms

 KIAA0147, SCRB1, Vartul

Description

 Scribbled planar cell polarity protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 143790920 - 143815379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180900 (version 83.38)

Entrez gene

 23513

UniProt

 Q14160 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14160

Antibodypedia

 SCRIB antibodies

PROTEIN BROWSER
SCRIB-001
SCRIB-002
SCRIB-003
SCRIB-004
SCRIB-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCRIB-001
ENSP00000322938
ENST00000320476
Q14160 [Direct mapping]
Protein scribble homolog
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0001921 [positive regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0031252 [cell leading edge]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0042734 [presynaptic membrane]
GO:0043065 [positive regulation of apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0050918 [positive chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060603 [mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0090630 [activation of GTPase activity]
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 1630 aa
174.9 kDa 		No 0
SCRIB-002
ENSP00000349486
ENST00000356994
Q14160 [Direct mapping]
Protein scribble homolog
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0001921 [positive regulation of receptor recycling]
GO:0002093 [auditory receptor cell morphogenesis]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0008105 [asymmetric protein localization]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0016080 [synaptic vesicle targeting]
GO:0016323 [basolateral plasma membrane]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0021747 [cochlear nucleus development]
GO:0030027 [lamellipodium]
GO:0031252 [cell leading edge]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0035748 [myelin sheath abaxonal region]
GO:0042060 [wound healing]
GO:0042734 [presynaptic membrane]
GO:0043065 [positive regulation of apoptotic process]
GO:0043615 [astrocyte cell migration]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050918 [positive chemotaxis]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060603 [mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0090630 [activation of GTPase activity]
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 1655 aa
177.7 kDa 		No 0
SCRIB-003
ENSP00000366756
ENST00000377533
Q14160 [Direct mapping]
Protein scribble homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0001921 [positive regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0031252 [cell leading edge]
GO:0034750 [Scrib-APC-beta-catenin complex]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0042734 [presynaptic membrane]
GO:0043065 [positive regulation of apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0050918 [positive chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060603 [mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0090630 [activation of GTPase activity]
Show all
 1549 aa
165.3 kDa 		No 0
SCRIB-004
ENSP00000431519
ENST00000526832
H0YCG0 [Direct mapping]
Protein scribble homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 650 aa
68.3 kDa 		No 0
SCRIB-007
ENSP00000433546
ENST00000531942
H0YDF9 [Direct mapping]
Protein scribble homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 140 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.