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OXTR

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GENERAL INFORMATION

Gene name

 OXTR

Gene description

 Oxytocin receptor

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, BJ hTERT+, HBF TERT88)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, BJ hTERT+, HBF TERT88)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 OXTR

Synonyms

Description

 Oxytocin receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 8750408 - 8769628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180914 (version 83.38)

Entrez gene

 5021

UniProt

 P30559 (UniProt - Evidence at transcript level)

neXtProt

 NX_P30559

Antibodypedia

 OXTR antibodies

PROTEIN BROWSER
OXTR-001
OXTR-002
OXTR-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OXTR-001
ENSP00000324270
ENST00000316793
P30559 [Direct mapping]
Oxytocin receptor
B2R9L7 [Target identity:100%; Query identity:100%]
Oxytocin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001967 [suckling behavior]
GO:0001975 [response to amphetamine]
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0004930 [G-protein coupled receptor activity]
GO:0004990 [oxytocin receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0005913 [cell-cell adherens junction]
GO:0006936 [muscle contraction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0007613 [memory]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0014070 [response to organic cyclic compound]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0017046 [peptide hormone binding]
GO:0021537 [telencephalon development]
GO:0030431 [sleep]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032355 [response to estradiol]
GO:0032570 [response to progesterone]
GO:0032870 [cellular response to hormone stimulus]
GO:0034059 [response to anoxia]
GO:0034097 [response to cytokine]
GO:0035176 [social behavior]
GO:0042220 [response to cocaine]
GO:0042277 [peptide binding]
GO:0042493 [response to drug]
GO:0042711 [maternal behavior]
GO:0042713 [sperm ejaculation]
GO:0042755 [eating behavior]
GO:0043434 [response to peptide hormone]
GO:0044058 [regulation of digestive system process]
GO:0044849 [estrous cycle]
GO:0045777 [positive regulation of blood pressure]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048545 [response to steroid hormone]
GO:0048565 [digestive tract development]
GO:0051965 [positive regulation of synapse assembly]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060137 [maternal process involved in parturition]
GO:0060406 [positive regulation of penile erection]
GO:0060455 [negative regulation of gastric acid secretion]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070474 [positive regulation of uterine smooth muscle contraction]
GO:1901652 [response to peptide]
Show all
 389 aa
42.8 kDa 		No 7
OXTR-002
ENSP00000414828
ENST00000431493
C9JQC4 [Direct mapping]
Oxytocin receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0004990 [oxytocin receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0032870 [cellular response to hormone stimulus]
GO:0035176 [social behavior]
GO:0042277 [peptide binding]
GO:0042711 [maternal behavior]
GO:0045907 [positive regulation of vasoconstriction]
GO:1901652 [response to peptide]
Show all
 43 aa
4.3 kDa 		No 0
OXTR-004
ENSP00000389587
ENST00000449615
C9JN09 [Direct mapping]
Oxytocin receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0004990 [oxytocin receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0032870 [cellular response to hormone stimulus]
GO:0035176 [social behavior]
GO:0042277 [peptide binding]
GO:0042711 [maternal behavior]
GO:0045907 [positive regulation of vasoconstriction]
GO:1901652 [response to peptide]
Show all
 92 aa
9.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.